目的 观察脑苷肌肽联合丁苯酞治疗老年脑梗死的临床疗效。方法 选取2011年3月—2014年5月佛山市三水区人民医院收治的老年脑梗死患者106例,随机分为对照组和治疗组,每组53例。对照组静脉滴注丁苯酞氯化钠注射液100 mL/次,2次/d。治疗组静脉滴注脑苷肌肽注射液20 mL,加入5%葡萄糖注射液300 mL,1次/d,其他治疗同对照组。两组均连续治疗14 d。比较两组的临床疗效,同时比较两组治疗前后的NIHSS、mRS评分和Barthel指数(BI)变化。结果 对照组和治疗组总有效率分别为73.58%、90.57%,两组比较差异有统计学意义(P < 0.05)。两组患者治疗后NIHSS评分、mRS评分均显著降低,BI显著升高,同组治疗前后差异有统计学意义(P < 0.05);治疗后治疗组这些观察指标改善程度优于对照组,两组比较差异有统计学意义(P < 0.05)。结论 脑苷肌肽联合丁苯酞治疗老年脑梗死患者的临床疗效显著,能够提高患者的生活质量,改善患者神经细胞的功能,值得临床推广应用。

Objective To observe the clinical effect of cattle encephalon glycoside and ignotin combined with butylphthalide in treatment of senium cerebral infarction. Methods The patients with senium cerebral infarction (106 cases) of Sanshui District People's Hospital of Foshan City from March 2011 to May 2014 were randomly divided into control and treatment groups, and each group had 53 cases. The patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily. The patients in the treatment group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection (20 mL diluted with 300 mL 5% glucose injection), once daily, and other treatment was the same as control group. The patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and the changes of NIHSS, mRS scores, and BI were compared. Results The efficacies in the control and treatment groups were 73.58% and 90.57%, respectively, and there were differences between two groups (P < 0.05). After treatment, NIHSS, and mRS scores in two groups were significantly reduced, while BI were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the indicators in treatment group improved better than those in control group, with the significant difference between two groups (P < 0.05). Conclusion Cattle encephalon glycoside and ignotin combined with butylphthalide has a good clinical effect in treatment of senium cerebral infarction, and can improve the life quality of patients and function of nerve cells, which is worth clinical promotion.