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[摘要]
目的 探讨度他雄胺联合坦索罗辛治疗老年良性前列腺增生的临床疗效。方法 收集2013年1月—2014年1月新疆维吾尔自治区人民医院收治的良性前列腺增生患者183例,随机分为对照组(92例)和治疗组(91例)。对照组口服盐酸坦索罗辛缓释胶囊1粒/次,1次/d。治疗组口服度他雄胺软胶囊,1粒/次,1次/d,同时口服盐酸坦索罗辛缓释胶囊,用法用量同对照组。两组患者均连续治疗24周。比较两组的临床疗效,同时比较两组治疗前,治疗8、16、24周最大尿流率(MFR)、残余尿量(RU)、前列腺体积(PV)、泌尿症状困扰(BS)评分、国际前列腺症状(IPSS)评分的变化。结果 对照组和治疗组总有效率分别为81.52%、90.11%,两组比较差异有统计学意义(P < 0.05)。治疗后,两组患者MFR均较治疗前显著升高,RU、PV、BS评分、IPSS评分均较治疗前显著降低,同组治疗前后差异有统计学意义(P < 0.05);且治疗组这些指标的改善程度优于对照组,两组比较差异有统计学意义(P < 0.05)。结论 度他雄胺联合坦索罗辛治疗老年良性前列腺增生有较好的临床疗效,可以缩小前列腺体积和膀胱残余尿量,改善患者下尿路症状,值得临床推广应用。
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[Abstract]
objective To investigate the clinical effect of dutasteride combined with tamsulosin in treatment of elderly benign prostatic hyperplasia. Methods The patients with benign prostatic hyperplasia (183 cases) of the People's Hospital of Xinjiang Uygur Autonomous Region from January 2013 to January 2014 were randomly divided into control (n= 92) and treatment (n= 91) groups. The patients in the control group were po administered with Tamsulosin Hydrochloride Sustained Release Capsules, 1 grain/time, once daily. The patients in the treatment group were po administered with Dutasteride Soft Capsules, 1 grain/time, once daily, and the usage and dosage of Tamsulosin Hydrochloride Sustained Release Capsules were the same as the control group. The patients in two groups were treated for 24 weeks. After treatment, the efficacy was evaluated, and maximum urinary flow rate (MFR), residual urine (RU), prostatic volume (PV), boring score (BS), and international prostate symptom score (IPSS) before and 8, 16, 24 weeks after the treatment in two groups were compared. Results The efficacies in the control and treatment groups were 81.52% and 90.11%, respectively, and there were differences between two groups (P < 0.05). After treatment, MFR in two groups were significantly higher, while the RU, PV, BS, and IPSS score were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Dutasteride combined with tamsulosin has the good clinical effect in treatment of elderly benign prostatic hyperplasia, and can reduce the prostate volume and bladder residual urine volume, while can improve lower urinary tract symptoms of patients, which is worth clinical promotion.
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