目的 观察固肾1号对大鼠抗肾小球基底膜(GBM)肾炎的治疗作用,并探讨其作用机制。方法 采用尾iv兔GMB血清免疫大鼠,制作大鼠Masugi肾炎实验模型。给药3周,观察固肾1号对大鼠尿蛋白含量、血液生化、肾脏系数、肾脏病理以及大鼠IgG、兔IgG在肾小球基底膜上沉积的影响。结果 固肾1号能显著降低尿蛋白含量,降低血清尿素氮(BUN)、肌酐(Cr)水平,升高血清总蛋白(Tp)、白蛋白(Alb)水平,并能降低肾脏系数,减轻肾脏病理改变及大鼠免疫球蛋白G(IgG)、兔IgG在肾小球基底膜上的沉积。结论 固肾1号能通过减少大鼠IgG、兔IgG在肾小球基底膜上的沉积,减轻肾脏病变,改善肾功能。

Objective To investigate the therapeutic effect of Gushen No. 1 on rat anti glomerular basement membrane (GBM) nephritis of rats, and study its possible mechanisms. Methods Rat anti-GBM antibody produced in rabbit was injected to rats to make Masugi nephritis model. After 3 weeks, index was observed after administrated Gushen No. 1, such as on urine protein, blood biochemistry, kidney index, kidney pathology, and IgG of rats and rabbit in GBM. Results Gushen No. 1 could significantly reduce rat's urine protein, serum urea nitrogen (BUN), serum creatinine (Cr), increase serum total protein (TP), and albumin (Alb). It also had therapeutic on significant reducing of renal index, improvement of kidney pathology, and reducing IgG of rats and rabbit in GBM. Conclusion It is obvious that Gushen No. 1 can alleviate kidney lesions and improve kidney function by reducing IgG of rats and rabbit in GBM.