[关键词]
[摘要]
目的 考察注射用氯诺昔康与盐酸托烷司琼注射液在0.9%氯化钠注射液中的配伍稳定性。方法 采用高效液相色谱法测定配伍溶液72 h内氯诺昔康与盐酸托烷司琼的含量, 并观察和检测配伍液的外观和pH值变化。结果 配伍溶液中氯诺昔康质量分数和pH值未见明显变化, 但盐酸托烷司琼质量分数随时间变化逐渐降低, 在2 h后质量分数低于60%, 且出现少量针状沉淀。结论 在室温条件下, 氯诺昔康与盐酸托烷司琼在0.9%氯化钠注射液中不稳定, 临床不宜混合使用用于术后镇痛。
[Key word]
[Abstract]
Objective To study the stability of Lornoxicam for injection with Tropisetron Hydrochloride Injection in 0.9 % sodium chloride injection. Methods Concentrations of lornoxicam and tropisetron hydrochloride in compatible solution were determined by HPLC method. The appearance of compatible solution was observed within 72 h. The changes in pH value of compatible solution were determined. Results No significant differences were found in the pH value and contents of lornoxicam, but the contents of tropisetron hydrochloride declined below 60% of the initial concentration and appearance of precipitation after 2 h. Conclusion The mixture of Lornoxicam for injection with Tropisetron Hydrochloride Injection in 0.9% sodium chloride injection is instability, and clinical application for patient controlled analgesia should be avoided.
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[基金项目]
十堰市科学技术研究与开发计划项目(14Y45)