[关键词]
[摘要]
目的 探讨通心络胶囊联合阿托伐他汀治疗急性心肌梗死PCI术后炎性反应的临床研究。方法 2011年6月—2014年6月衡水市第二人民医院收治的急性心肌梗死患者80例, 随机分为对照组和治疗组, 每组40例。对照组在基础治疗上口服阿托伐他汀钙胶囊, 2粒/次, 1次/d。治疗组在对照组基础上加用通心络胶囊, 4粒/次, 3次/d。两组均连续用药3个月。比较两组患者治疗前后气虚血瘀症状和SAQ评分, 同时比较两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、细胞间黏附因子(ICAM-1)和白细胞介素-6(IL-6)、N末端B型利钠肽原(NT-proBNP)水平。结果 治疗后, 两组患者气虚血瘀症状评分较同组治疗前显著降低, SAQ评分显著升高, 同组治疗前后差异有统计学意义(P<0.05);且治疗组气虚血瘀症状和SAQ评分改善程度优于对照组, 两组比较差异有统计学意义(P<0.05)。治疗后, 两组患者的炎症因子CRP、TNF-α、IL-6、ICAM-1和NT-proBNP均较治疗前显著降低, 同组治疗前后差异有统计学意义(P<0.05);且治疗后治疗组各因子水平均低于对照组, 两组比较差异有统计学意义(P<0.05)。结论 通心络胶囊联合阿托伐他汀治疗急性心肌梗死PCI术后炎性反应具有较好的临床疗效, 可改善患者临床症状, 同时能够降低患者术后炎症因子水平, 具有临床推广价值。
[Key word]
[Abstract]
Objective To explore the clinical study on Tongxinluo Capsules combined with atorvastatin in treatment of acute myocardial infarction with PCI postoperative inflammatory reaction. Methods The patients with acute myocardial infarction (80 cases) of the Second People's Hospital of Hengshui from June 2011 to June 2014 were randomly divided into treatment and control groups, and each group had 40 cases. The patients in the control group were po administered with Atorvastatin Calcium Capsules on the basis of conventional treatment, two capsules/time, once daily. The patients in the treatment group were po administered with Tongxinluo Capsules on the basis of the control group, four capsules/time, three times daily. The patients in two groups were treated for three months. Qixu Xueyu symptoms and SAQ scores before and after treatment in two groups were compared, while the levels of CRP, TNF-α, ICAM-1, IL-6, and NT-proBNP in two groups were compared. Results After treatment, Qixu Xueyu symptoms scores in two groups were significantly reduced, while SAQ scores in two groups increased significantly, and the difference was statistically significant in the same group before and after treatment (P < 0.05). After treatment, Qixu Xueyu symptoms and SAQ scores in the treatment group improved better than those in the control group, and there were differences between two groups (P< 0.05). After treatment, CRP, TNF-α, IL-6, ICAM-1, and NT-proBNP in two groups were significantly reduced, and the difference was significant in the same group before and after treatment (P < 0.05). After treatment, the levels of those inflammatory factors were lower than those in the control group, and there were differences between the two groups (P < 0.05). Conclusion Tongxinluo Capsules combined with atorvastatin has a good clinical effect on treatment of acute myocardial infarction with PCI postoperative inflammatory reaction, and can improve clinical symptoms, while can reduce the levels of inflammatory factors, which is worth clinical promotion.
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[基金项目]
河北省衡水市科学技术研究与发展指导计划项目(11024Z)