目的 研究桂枝茯苓胶囊对大鼠实验性肠系膜微循环障碍的影响。方法 将75只SD雌性大鼠随机分为5组, 分别为模型组、盐酸消旋山莨菪碱注射液(0.50 mg/只, im给药)组以及桂枝茯苓胶囊低、中、高剂量(0.14、0.27、0.54 g/kg, ig给药)组, 1次/d, 连续7 d。末次给药后30 min开腹找出肠系膜, 观察滴加肾上腺素后选定区域的微动脉管径、微静脉管径、微动脉流速、微静脉流速及局部微循环血流恢复时间。结果 局部区域滴加1:100盐酸肾上腺素生理盐水溶液20 μL/只后, 观察区出现了典型的微循环障碍的表现。桂枝茯苓胶囊对微动脉管径、微静脉管径, 微动脉流速, 微静脉流速及局部微循环血流恢复时间均有显著的改善作用。结论 桂枝茯苓胶囊具有改善微循环障碍作用。

Objective To study the effects of microcirculatory disturbance with Guizhi Fuling Capsules in rats. Methods Seventy-five SD female rats were randomly divided into model group, Raceanisodamine Hydrochloride Injection (0.50 mg each,, im administration) group, Guizhi Fuling Capsules low-, mid-, and high-dose (0.14, 0.27, and 0.54 g/kg, ig administration) groups. At the same time mice were given drugs 1 once daily for 7 d. Thirty minutes after intragastric administration on the 7th day, added epinephrine and observed the micro artery diameter, microvein diameter, micro artery flow velocity, micro vein flow velocity, and recovery time of blood flow. Results 20 μL of Adrenaline Saline Solution (1:100) was added into in local area and appeared typically microcirculatory disturbance. Guizhi Fuling Capsules could improve significantly the microartery diameter, micro vein diameter, micr oartery flow velocity, micro vein flow velocity, and recovery time of blood flow. Conclusion Guizhi Fuling Capsules can improve microcirculation obstacles.

国家重大新药创制项目(2013ZX09402203)