血管性痴呆是指由于各种脑血管疾病所导致的获得性智能障碍综合症.随着人口的老龄化、饮食结构的改变,血管性痴呆的发病率呈逐年增加的趋势.奥拉西坦是一种代表性的具有吡咯烷酮结构的促智药,临床上用于治疗健忘症、老年性痴呆、血管性痴呆等.近年来有关奥拉西坦单独或联合用药治疗血管性痴呆的研究越来越多,特别是联合用药,通过不同药物的协同作用显著提高血管性痴呆的治疗效果.对奥拉西坦及其联合用药治疗血管性痴呆临床应用的研究进展进行综述,为血管性痴呆的临床用药提供参考.

Vascular dementia (VD) is a kind of cognitive dysfunction caused by a number of cardiovascular diseases. With the aging of the population and changes in diet, VD incidence showed a rising trend. Oxiracetam is a representative nootropic drug with the structure of pyrrolidone used for the treatment of amnesia, Alzheimer's disease, vascular dementia, etc. In recent years, there are more and more studies on single or combination therapy with oxiracetam, especially the combination therapy, the results indicate that the combination of drugs through different mechanisms and synergy can significantly improve the therapeutic effect of VD. The research progress on the single or combined use of oxiracetam is introduced in this article. It could provide a reference for clinical treatment of vascular dementia.

辽宁省教育厅科学研究一般项目(L2012146)