目的 探讨西帕依固龈液联合氟康唑治疗老年义齿性口炎的疗效.方法 选取2013年1月—2013年10月中国人民解放军第451医院收治的义齿性口炎患者42例,随机分为对照组和治疗组,每组21例.对照组口服氟康唑片,1片/次,1次/d,首次剂量加倍.治疗组在对照组基础上给予西帕依固龈液含漱,5 mL/次,含漱时间3 min,3次/d.两组均连续治疗6个月.比较两组的临床疗效,同时观察两组定植菌的菌群变化及口炎复发率.结果 治疗后,对照组和治疗组的显效率分别为85.71%、95.24%,总有效率分别为95.24%、100.00%,两组比较差异有统计学意义(P<0.05).治疗15 d、治疗后、复诊时两组白色念珠菌、链球菌、乳杆菌的菌落总数均较治疗前显著降低,同组比较差异有统计学意义(P<0.05);且治疗组白色念珠菌、乳杆菌的菌落总数少于对照组,两组比较差异有统计学意义(P<0.05).对照组和治疗组复发率分别为42.86%、23.81%,两组比较差异具有统计学意义(P<0.05).结论 西帕依固龈液联合氟康唑治疗老年义齿性口炎具有较好的临床疗效,可降低白色念珠菌和乳杆菌的感染,降低复发率,值得临床推广应用.

Objective To investigate the clinical effect of Xipayi Mouth Rinse combined with fluconazole in treatment of denture stomatitis. Methods The patients with elderly denture stomatitis (42 cases) of the 451^th Hospital of PLAfrom January 2013 to October 2013 were randomly divided into control and treatment groups, and each group had 21 cases. The patients in the control group were po administered with Fluconazole Tablets, one tablet/time, once daily. And the dosage of first time was double. The patients in the treatment group were given Xipayi Mouth Rinse, 5 mL/time for 3 min, three times daily. The patients in two groups were treated for 6 months. After the treatment, the efficacy was evaluated, while the changes of engraftment bacteria flora and recurrence rate of stomatitis in two groups were observed. Results The significant efficiencies in the control and treatment groups were 85.71% and 95.24%, and the efficacies in two groups were 95.24% and 100.00%, respectively, with significant difference between the two groups (P < 0.05). After treatment for 15 d, after treatment, and return visit, total numbers of colonies of Candida albicans, Streptococcus, and Lactobacillus were significantly reduced before treatment, and the difference was statistically significant in the same group (P < 0.05). And numbers of colonies of C. albicans and Lactobacillus in treatment group were less than those in the control group, with significant difference between two groups (P < 0.05). The recurrence rate in control and treatment groups were 42.86% and 23.81%, respectively, with significant difference between two groups (P < 0.05). Conclusion Xipayi Mouth Rinse combined with fluconazole has the good clinical effect in treatment of elderly denture stomatitis, and can reduce the infection of C. albicans and Lactobacillus, while can reduce the recurrence rate, which can be used widely in clinic.