目的 观察固肠胶囊对慢性溃疡性结肠炎的影响,并探讨其可能的作用机制.方法 采用复合型慢性溃疡性结肠炎、脾虚型慢性溃疡性结肠炎实验模型,角叉菜胶致大鼠足肿胀、小鼠毛细血管通透性、大鼠棉球肉芽肿实验模型,观察固肠胶囊对慢性溃疡性结肠炎的治疗作用.结果 固肠胶囊能明显降低复合型慢性溃疡性结肠炎的结肠指数(CI)和疾病活动指数(DAI)、明显降低结肠IL-6、IL-8水平,明显减轻结肠黏膜病变;明显减少脾虚型慢性溃疡性结肠炎的溃疡面积和溃疡个数,明显减轻结肠黏膜病变,明显降低棉球肉芽的质量,对大鼠足肿、小鼠毛细血管通透性无明显影响.结论 固肠胶囊通过降低结肠IL-6、IL-8水平,减轻慢性炎症,以达到治疗慢性溃疡性结肠炎的目的.

Objective To investigate the effect and possible mechanisms of Guchang Capsules on chronic ulcerative colitis in rats and mice. Methods Complex type chronic ulcerative colitis, spleen deficient experimental model of chronic ulcerative colitis, carrageenan inducing foot swelling of rats, capillary permeability in mice, rat granuloma induced by cotton ball experiment mode were used, and effect of Guchang Capsules on chronic ulcerative colitis were studied. Results Guchang Capsules could obviously reduce colon index (CI) and disease activity index (DAI) of chronic ulcerative colitis, significantly lower colon IL-6, IL-8 levels, significantly reduce colon mucosa lesions, ulcer area and ulcer number of spleen deficient type of chronic ulcerative colitis, and also significantly reduce the weight of cotton ball granuloma. There was no obvious effect on rats foot swelling and capillary permeability in mice. Conclusion It is obvious that Guchang Capsules can relieve chronic ulcerative colitis by lowering colon IL-6 and IL-8 levels and reducing chronic inflammation.