白屈菜碱是白屈菜Chelidonium majus的主要活性成分之一,属于苯并菲啶类生物碱,现作为止痛药应用于临床.随着对白屈菜碱药理作用的深入研究发现,其具有抗肿瘤、镇痛、抗菌、解痉等多种药理作用,且其抗肿瘤作用越来越受到关注.对近年来白屈菜碱药理作用的国内外研究进展做以综述,为其进一步研究与应用提供理论依据.

Chelidonine, a benzophen anthridine alkaloid, is one of the main effective constituents of Chelidonium majus, which is applied as a painkiller in clinical treatment. The further studies on the pharmacological activities in recent years have demonstrated that chelidonine plays a role in antitumor, analgesic, antibacterial, spasmolysis activities, etc. And the antitumor activity is paid more and more attention. In this paper, research progress on pharmacological activities and mechanisms of chelidonine home and abroad in recent years are reviewed, which could provide a theoretical basis for the further study and application of C. majus.

国家自然科学基金资助项目(81102858);中国博士后科学基金资助项目(2013M531060);黑龙江省自然科学基金资助项目(D200817);黑龙江省博士后科研基金项目(LBH-Z11103);黑龙江省教育厅骨干教师项目(1154G35)