目的 探讨复方甘草酸苷注射剂致过敏性休克的临床特点及规律,为合理用药提供参考.方法 检索中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(维普)、万方数字化期刊全文库等数据库,对涉及病例的文献进行分析和讨论.结果 复方甘草酸苷注射剂致过敏性休克17例,其发生与患者年龄、性别无明显关系;其中15例(88.2%)发生在首次给药后的20 min内,临床表现及解救方法与其他过敏性休克无明显差异.经积极的抗过敏性休克抢救,全部病例恢复正常,无死亡病例.医务人员对患者用药初期出现的不良反应不够重视是发生过敏性休克的安全隐患.结论 复方甘草酸苷注射剂致过敏性休克并不罕见,医务人员应予以重视.

Objective To explore the clinical characteristics and rules of anaphylactic shock induced by Compound Glycyrrhizin Injection, and to provide the references for the rational use of drugs in clinic. Methods China Journal Full-text Database (CNKI), Chinese Science and Technology Journal Full-text Database (VIP), Wangfang Database, etc were retrieved, and the literature involving cases were analyzed and discussed. Results There were 17 anaphylactic shock cases caused by Compound Glycyrrhizin Injection, and they had no obvious relationship with age and gender. Fifteen cases (88.2%) occured in the medication within 20 min after iv infusion. There was no significant difference in clinical manifestations and rescue compared with other anaphylactic shock. After active anti-anaphylactic shock rescue, all patients returned to normal with no deaths. It was the security risk to anaphylactic shock that medical staff didn't pay attention to ADR at the initial treatment stage. Conclusion Anaphylactic shock induced by Compound Glycyrrhizin Injection is not rare, and clinical medical workers should pay attention to it.