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[摘要]
目的 对4-氯-2-氧代-1,2-二氢喹啉-3-甲醛的合成工艺进行研究。方法 以苯胺为原料通过酯的氨解、环合、胺亚甲基化、水解反应得到目标化合物。结果 合成了目标化合物,并利用MS和1H-NMR确证了结构,此路线所得产品收率为62.1%。结论 此路线操作简单,成本低廉,设计合理,收率高,适合该化合物的工业化生产。
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[Abstract]
Objective To study the synthetic technology of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carbaldehyde. Methods N1, N3-diphenylmalonamide was used as starting material to synthesize the target compound by ammonolysis of ester, cyclization, methylation of amine, and hydrolysis reaction. Results The target compound was synthesized and characterized by MS and 1H-NMR. The yield of this route was 62.1%. Conclusion The synthetic route for the compound has the advantages of simple operation, low cost, reasonable design, and high yield, which is suitable for the industrial production of the compound.
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