T型钙通道是一种低电压钙通道，在体内分布广泛，参与多种生理过程。T型钙通道阻滞剂是目前关注较多的一种新型钙通道阻滞剂，除具备与传统钙通道阻滞剂相似的降压作用外，还具有如降低心肌自律性、抗心肌重塑、保护肾功能、抗交感神经等药理作用。对T型钙通道阻滞剂的药理作用、药物相互作用与不良反应等研究进展进行综述，从而了解T型钙通道阻滞剂在临床实践中的应用现状，探索和开发其在临床实践中的新使用价值。

T-type calcium channel is a kind of low voltage calcium channel, widely distributed throughout the body and participates in many physiological activities. Now increasing attention has been focused on the blockers of the T-type calcium channel. It has not only the function of lowing blood pressure like traditional calcium channel blockers, but also some pharmacological activities such as inhibiting cardiac muscle autorhythmicity, anti-cardiovascular remodeling, renal protective action, and resistance to the sympathetic nervous. This paper summarizes the pharmacological activities, drug interaction, and side effects of T-type calcium channel blockers, which helps to understand the application status of the T type calcium channel blockers in clinical practice, and explore and develop new use value of T-type calcium channel blockers.

国家“重大新药创制”科技重大专项资助项目（2012ZX09303-008-001）；2010年国家临床重点专科建设项目