目的 建立离子色谱法测定炎琥宁原料药中碳酸盐残留的方法。方法 采用离子色谱法。色谱柱：Dionex IonPac AS18（250 mm×4 mm）；淋洗液：0.022 mol/L氢氧化钾；体积流量：1.0 mL/min；进样体积：10 μL；柱温：30 ℃；检测器：电导检测器；检测池温度：35 ℃；抑制器：Dionex ASRS 300（4 mm）。结果 CO₃^2-与Cl^-、NO₂^-、NO₃^-、SO₄^2-分离良好，CO₃^2-在10～120 μg/mL与峰面积呈良好的线性关系（r=0.999 0）；平均回收率为102.1%，RSD值为3.7%（n=9）。结论 该方法灵敏、准确、简便，专属性好，可用于测定炎琥宁原料药中碳酸盐的残留。

Objective To establish a method to determine the residual of carbonate in potassium sodium dehydroandroan drographolide succinate by ion chromatography. Ion chromatography was used. The separation was carried out on a Dionex IonPac AS18 column (250 mm × 4 mm) with 0.022 mol/L KOH as mobile phase. The injection volume was 10 μL at the flow rate of 1.0 mL/min. The temperature of column was set at 30 ℃. Conductivity detector with temperature of detector cell 35 ℃ was used. Dionex ASRS 300 (4 mm) was used as suppressor.Results There was good separation between CO₃^2- and Cl^-, NO₂^-, NO₃^-, and SO₄^2-. The standard curve was rectilinear in the range of 10 — 120 μg/mL (r=0.999 0). The average recovery was 102.1% with RSD value of 3.7% (n = 9). Conclusion This method is accurate, simple, and selective which could be used for the determination of the residual of carbonate in potassium sodium dehydroandroan drographolide succinate.