目的 探讨银锌霜治疗Ⅱ度烧伤患者污染创面的临床疗效。方法 选取2011年3月-2014年2月来上海交通大学医学院附属第三人民医院就诊的Ⅱ度烧伤患者102例，随机分为治疗组和对照组，每组51例。对所有患者进行及时的清创及创口清洗处理，并给予常规补液、镇痛等处理。治疗组加用银锌霜进行外用涂敷治疗，1次/d。对照组加用湿润烧伤膏外用涂敷，3次/d。每次均涂抹外用药物适量于创面并进行包扎处理，并依据患者病情决定药物使用时间。比较两组患者的换药次数、愈合时间、抗生素使用时间、住院时间、创面愈合情况等。结果 治疗组患者的换药次数、愈合时间、抗生素应用时间及住院时间均明显短于对照组，两组比较差异有统计学意义（P<0.05）。治疗4 d、1周、2周后治疗组浅Ⅱ度和深Ⅱ度烧伤患者的创口愈合率均明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗过程中两组患者均出现创面加深、创面脓毒症、创面异味等不良事件，治疗组创面异味的发生率明显低于对照组，两组比较差异有统计学意义（P<0.05）；治疗组无高热发生，对照组高热的发生率为7.84%，两组比较差异有统计学意义（P<0.05）。结论 银锌霜对Ⅱ度烧伤患者污染创面有较好的临床疗效，可明显改善患者创面愈合状况，值得临床推广应用。

Objective To explore the efficacy of Silver-zinc Cream in the treatment of degree Ⅱ burn with contamination wounds. Methods The patients suffered form degree Ⅱ burn (102 cases) in No.3 People Hospital Affiliated to Shanghai Jiaotong University School of Medicine from March 2011 to February 2014 were randomly divided into treatment and control groups, and there were 51 cases in each group. All the patients were given debridement and wound cleaning processing, and were given regular rehydration and analgesic treatment. The patients in the treatment group used Silver-zinc Cream for external coating treatment, once daily; The patients in the control group used Moist Burn Cream for external coating treatment, 3 times daily. The drugs were applied right amount thickness in the treatment of wound by bandaged and the drug usage time was decided according to the condition of patients. Switching frequency, time of healing, antibiotic usage, hospital stay, and situation of wound healing were compared. Results Switching frequency, time of healing, antibiotic usage, hospital stay, and situation of wound healing in the treatment group are significantly shorter than those in the control group, with the significant difference between the two groups (P < 0.05). Burn wound healing rate was significant difference between the two groups (P < 0.05). Burn wound healing rate of shallow degree Ⅱ and deep degree Ⅱ in the treatment group for 4 d, 1 week, and 2 weeks after the treatment were significantly higher than those in the control group, with the significant difference between the two groups (P < 0.05). Adverse events of wound deepened, sepsis, and wound odor were happened in the two groups. Incidence of wound odor in the treatment group was obviously lower than that in the control group, with the significant difference between the two groups (P < 0.05). There was no fever in the treatment group, while the incidence of fever in the control group was 7.84%, with the significant difference between the two groups (P < 0.05). Conclusion Silver-zinc Cream has a good clinical efficacy in the treatment of degree Ⅱ burn with contamination wounds, and could obviously improve the condition of wound healing, which is worthy of clinical application.

国家自然科学基金资助项目（81071567）