目的 表征N-硬脂酰酪氨酸及其盐的理化常数和血浆蛋白结合率。方法 采用摇瓶法及HPLC-UV法测定N-硬脂酰酪氨酸及其盐在不同介质和pH值下的溶解度、表观脂水分配系数，采用平衡透析法测定血浆蛋白结合率。结果 N-硬脂酰酪氨酸盐的溶解度和血浆蛋白结合率明显优于其原型药物；N-硬脂酰酪氨酸的溶解度为（27.62±0.43）mg/L，其二钾盐的溶解度为（51.70±0.29）mg/L；N-硬脂酰酪氨酸及其二钾盐的血浆蛋白结合率分别为20.96%～23.11%、35.41%～40.38%。结论 N-硬脂酰酪氨酸成盐后其理化性质得到明显改善。

Objective To characterize the physicochemical parameters and plasma binding ratio of N-stearoyltyrosine and its salts. Methods The solubility, the apparent partition coefficient of N-stearoyltyrosine and its salts in various media, and different pH values were measured via a shake flask method and high performance liquid chromatography with ultraviolet detection (HPLC-UV) method. The plasma protein binding ratio was conducted under dialysis equilibrium method. Results The solubility and plasma binding ratio of N-stearoyltyrosinates were better than those of N-stearoyltyrosine. The solubility of N-stearoyltyrosine was (27.62 ± 0.43) mg/L while that of dipotassium N-stearoyltyrosine (NsTyr-2K) (51.70 ± 0.29) mg/L. The plasma protein binding ratios were 20.96%-23.11% and 35.41%-40.38% for N-stearoyltyrosinate and NsTyr-2K, respectively. Conclusion It has the significant improvement of physicochemical properties of N-stearoyltyrosine after formation of salt.

国家自然科学基金资助项目（30873057，81171245）；上海市科委基础重点课题（11JC1406600）；上海市科委科技支撑项目（12431900604）