目的 对3-异丁基戊二酰亚胺的合成工艺进行研究。方法 以异戊醛为原料，经Knoevenagel缩合、Michael加成、水解脱羧、环合得到目标产物。结果 合成了目标化合物，并利用IR、MS和¹H-NMR确证了结构；收率为78.0%，质量分数为98.5%。结论 采用“一勺烩”合成了3-异丁基戊二酰亚胺，操作简便，设计合理，收率较高。

Objective To study the synthetic technology of 3-isobutyl glutarimide. Methods 3-Methyl butanal was used as starting material to synthesize the target compound by Knoevenagel condensation, Michael addition, hydrolysis decarboxylation and cyclization. Results The target compound was synthesized and characterized by IR, MS and ¹H-NMR. The yield was 78.0% and the purity was 98.5%. Conclusion 3-Isobutyl glutarimide is synthesized using the method of "one-pot" which has the advantages of simple operation and reasonable design with high yield.

天津市科技计划项目（13ZCZDSY00100）