目的 评价和分析天津市津南区咸水沽医院2011-2013年抗菌药物使用情况及趋势，为临床用药的合理性和科学性提供参考。方法 从天津市津南区咸水沽医院HIS系统中调取2011-2013年的抗菌药物销售数据进行回顾性分析，对抗菌药物的品种、销售数量、销售金额和用药频度（DDDs）以及使用比例进行统计分析。结果 抗菌药物的DDDs逐年下降，使用频率高的抗菌药物以头孢菌素和大环内酯类为主。结论 天津市津南区咸水沽医院2011-2013年抗菌药物应用总体上比较规范和合理，基本符合抗菌药物的用药规律，特别是开展抗菌药物临床应用专项整治活动后，抗菌药物应用总量呈下降趋势，品种的选择日趋规范。

Objective To evaluate and analyze the application and trend of antimicrobial drugs in Jinnan Xianshuigu Hospital of Tianjin City during 2010-2013, so as to provide scientific evidence for the rationality and saftey of drug usage. Methods The antibacterial drugs sales data from the HIS system during 2010-2013 were retrospectively analyzed, including the antimicrobial varieties, sales volume, sales amount, and frequency of drug use (DDDs), and the use proportion of antibiotics. Results The antimicrobial DDDs decreased year by year. Cephalosporins and macrolides were commonly used antimicrobial drugs with high use frequency. Conclusion In general, the application of antibiotics in Jinnan Xianshuigu Hospital of Tianjin City during 2010-2013 is up to the standard and reasonable, according with the laws of antibacterial drugs. Especially, after the government of clinical antibacterial drugs application, the total antimicrobial drugs consumption shows a declined tendency and the choice of varieties is being more accordance with the standard.