[关键词]
[摘要]
目的 探讨改性几丁质喷雾剂对口腔溃疡的改善作用。方法 选取2011年6月-2013年12月到梧州市红十字会医院口腔科就诊的口腔溃疡患者90例,随机分为改性几丁质组(30例)、康复新液组(30例)、对照组(30例),治疗前所有患者漱口保持口腔清洁,改性几丁质组患者采用改性几丁质喷雾剂喷到患处,作用3 min后漱口,3次/d;康复新液组含康复新液3 min后吞服,10 mL/次,3次/d;对照组采用0.9%氯化钠注射液含漱,停留3 min,3次/d。3组用药直至口腔溃疡愈合。3组均服用维生素A、C、B2等药物5 d。比较3组患者灼痛消失时间、红肿消失时间、溃疡愈合时间、治疗时间和总有效率。结果 改性几丁质组、康复新液组、对照组的总有效率分别为100.0%、83.3%、60.0%,对照组的总有效率与其他两组比较差异均有统计学意义(P<0.05);改性几丁质组的总有效率显著高于康复新液组,两组比较差异有统计学意义(P<0.05)。改性几丁质组、康复新液组的灼痛消失时间、红肿消失时间、溃疡愈合时间和治疗时间均明显短于对照组,差异有统计学意义(P<0.05);改性几丁质组的这些观察指标均明显短于康复新液组,两组比较差异有统计学意义(P<0.05)。结论 改性几丁质喷雾对口腔溃疡有较好的临床疗效,能显著缩短疼痛和愈合时间,值得临床推广应用。
[Key word]
[Abstract]
Objective To explore the curative effect of modified chitin spray in improvement of oral ulcers. Methods Patients (90 cases) with oral ulcers for the treatment in Department of Stomatology, Wuzhou Red Cross Hospital during June 2011 to December 2013 were randomly divided into modified chitin, Kangfuxin Liquid, and control groups (30 cases in each group). All the patients rinsed mouth to keep oral cavity clean before treatment. The patients in modified chitin group were treated with modified chitin spray onto the affected area for 3 min and rinsed mouth, 3 times daily. The patients in Kangfuxin Liquid group were treated with Kangfuxin Liquid in mouth for 3 min and than swallowed, 10 mL/time, 3 times daily. Patients in control group used 0.9% Sodium Chloride Injection for mouthwash, and stayed for 3 min, 3 times daily. The patients in three groups were administered until the ulcer healing. All patients took vitamins A, C, and B2 for 5 d. The burn disappearing time, swelling disappearing time, ulcer healing time, treatment time, and total effective rate in three groups were compared. Results The efficacies on the patients in modified chitin, Kangfuxin Liquid, and control groups were 100.0%, 83.3%, and 60.0%, and total effective rate in the control group was lower than that in the other two groups with significant difference between the two groups (P < 0.05). The total effective rate in modified chitin group was higher than that in Kangfuxin Liquid group with significant difference (P < 0.05). The burn disappearing time, swelling disappearing time, ulcer healing time, and treatment time in modified chitin and Kangfuxin Liquid groups were significantly shorter than those in the control group with significant difference (P < 0.05). Those indexes in modified chitin group were significantly lower than those in Kangfuxin Liquid group with significant difference between the two groups (P < 0.05). Conclusion Modified chitin spray has a good clinical efficacy in the treatment of oral ulcers, and can significantly reduce the pain and healing time, which is worthy of clinical popularization and application.
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[基金项目]
教育部高等学校博士学科点专项科研基金资助项目(20100101120114)