目的 观察长春西汀联合巴曲酶治疗突发性耳聋的临床疗效。方法 选取2013年1月-2014年1月就诊于武汉市第三医院的突发性耳聋患者100例，随机分为治疗组和对照组，每组50例。对照组在常规治疗的基础上静脉滴注巴曲酶注射液，10 BU/次，隔天1次，共使用5次；治疗组静脉滴注长春西汀注射液，20 mg/d，其他同对照组。两组均治疗10 d。观察两组患者的临床疗效，检测血浆凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）、血浆纤维蛋白原（Fg）和血液流变学指标变化。结果 治疗后，治疗组和对照组的总有效率分别为86%、60%，两组比较差异有统计学意义（P<0.05）。治疗后两组患者PT、TT、APTT较治疗前延长，治疗后两组Fg水平均低于治疗前，同组治疗前后差异有统计学意义（P<0.05）。治疗后，治疗组和对照组的血浆黏度、全血黏度高切、全血黏度低切、红细胞压积均较治疗前有所降低，同组治疗前后差异有统计学意义（P<0.05）；治疗后，治疗组这些指标较对照组改善更加明显，两组比较差异有统计学意义（P<0.05）。结论 长春西汀联合巴曲酶对突发性耳聋具有较好的临床疗效，可以改善患者血液高凝状态和局部微循环，值得临床推广使用。

Objective To observe the clinical efficacy of vinpocetine combined with batroxobin in the treatment of sudden deafness. Methods Patients (100 cases) with sudden deafness for the treatment in Wuhan Third Hospital from January 2013 to January 2014 were randomly divided into treatment and control groups (50 cases in each group). The patients in the control group were iv administered with Batroxobin Injection on the basis of conventional treatment, 10 BU/time, once every other day, and used for 5 times. The patients in the treatment group were iv administered with Vinpocetine Injection, 20 mg/d, and other treatment was the same as the control group. The patients in two groups were treated for 10 d. The total clinical efficacy was observed, and the changes of PT, TT, APTT, Fg, and hemodynamic indexes were detected. The total effective rates of treatment and control groups were 86% and 60%, respectively, with significant difference between the two groups (P < 0.05). After treatment, PT, TT, and APTT was longer, and Fg was lower compared with before treatment in the two groups, and the difference was statically significant in the same group before and after treatment (P < 0.05). After treatment, plasma viscosity, whole blood high shear viscosity, low sheer viscosity, and blood hematocrit were lower compared with those before treatment in the two groups, and the difference was statically significant in the same group before and after treatment (P < 0.05). After treatment, those indexes in the treatment group were improved more obvious than those in the control group, with significant difference between the two groups (P < 0.05). Conclusion Vinpocetine combined with batroxobin has a good clinical efficacy in the treatment of sudden deafness, and can improve the blood high condensation state and local microcirculation of patients, which is worthy of clinical application.

国家自然科学基金资助项目（30872864）