目的 制定瑞舒伐他汀钙片溶出度的测定方法。方法 采用桨板法优化溶出试验条件，紫外-可见分光光度法在241 nm处进行吸光度测定。结果 瑞舒伐他汀钙片溶出方法：以水900 mL（规格10、20 mg）、500 mL（规格5 mg）为溶出介质，转速50 r/min，30 min后取样，照紫外-可见分光光度法在241 nm处测定。结论 建立的方法准确、简便，测定结果均一性良好，均能够在30 min溶出完全，可有效地用于瑞舒伐他汀钙片溶出度的测定。

Objective To establish a dissolution method for Rosuvastatin Calcium Tablets. Methods Paddle method was used to optimize the dissolution test conditions and the absorbance was measured at 241 nm by UV-visible spectrophotometer. Results The dissolution method of rosuvastatin calcium was based on water 900 mL (Size 10 mg and 20 mg) and 500 mL (size 5 mg) at the speed of 50 r/min. After 30 min the test started, the sample was measured at 241 nm according to UV-visible spectrophotometry. Conclusion The method is accurate, simple, and effective with good uniformity and capable of dissolution in 30 min for the determination of dissolution of rosuvastatin calcium in Rosuvastatin Calcium Tablets.

国家科技重大专项资助项目（2011ZX09203-002）