目的 探讨多索茶碱片联合噻托溴铵粉雾剂治疗煤工尘肺的疗效。方法 将北京京煤集团总医院2011年11月-2012年10月收治的90例煤工尘肺患者随机分为治疗组和对照组，各45例，对照组在常规治疗基础上口服多索茶碱片，0.2 g/次，2次/d；治疗组联合使用噻托溴铵粉雾剂，18 μg/d，吸入给药；两组均治疗4周，比较两组患者治疗前后临床症状及肺功能情况。结果 治疗后治疗组临床症状显著优于对照组，两组相比差异具有统计学意义（P<0.05）；治疗3个月后，治疗组各肺功能指标明显改善，与治疗前相比差异具有统计学意义（P<0.05），且治疗3、6个月后治疗组肺功能指标显著优于同时段对照组，两组间相比差异也有统计学意义（P<0.05）。结论 多索茶碱片联合噻托溴铵粉雾剂能够改善煤工尘肺患者临床症状，提高患者肺功能，疗效确切，不良反应少，值得临床推广应用。

Objective To explore the effects of Doxofylline Tablets combined with Tiotropium Bromide Powder for inhalation on pulmonary function of coal workers' pneumoconiosis. Methods Patients (90 cases) with coal workers' pneumoconiosis of Beijing Jingmei Group General Hospital from November 2011 to November 2012 were randomly divided into treatment group and control groups (45 cases in each group). On the basis of conventional treatment, the patients in the control group were po administered with Doxofylline Tablets 0.2 g once, twice daily. While the patients in the treatment group were administered combined with Tiotropium Bromide Powder Spray 18 μg daily. The patients in the both groups were treated for 4 weeks. The clinical symptoms and pulmonary function were compared for the patients between the two groups. Results After the treatment, the clinical symptoms in the treatment group improved more significantly than those in the control group, with statistically significant difference between the two groups (P < 0.05). After 3 months of the treatment, the pulmonary function of the patients in the treatment group were improved significantly, and the difference was statistically significant (P < 0.05). After the treatment for 3 and 6 months, the lung function index was significantly higher than that of the patients in the control group at the same time, and there were significant differences between the two groups (P< 0.05). Conclusion Doxofylline Tablets combined with Tiotropium Bromide Powder for Inhalation can improve the clinical symptoms in the patients with coal workers' pneumoconiosis, and pulmonary function with less adverse reaction. It is worthy of clinical application.