目的 探讨益生菌辅助治疗对婴幼儿湿疹的临床疗效和安全性。方法 抽选眉山市人民医院收治的100例婴幼儿湿疹患者，随机分为对照组（50例）和治疗组（50例），对照组采用常规治疗。治疗组在对照组的基础上加用纽曼斯益生菌辅助治疗，1岁以内患儿半粒/d，1岁以上1～2粒/d，在两餐中间，餐前空腹服用，两组均治疗4周后评价疗效。结果 两组患者治疗后，治疗组和对照组的总有效率分别为92.0%、78.0%，两组比较差异有统计学意义（P＜0.05）。治疗组治疗后2、3个月湿疹的复发率分别为6%、8%，明显低于对照组的18%、28%，两组比较差异均有统计学意义（P＜0.05）。治疗4周后治疗组患者IL-10、IFN-α等细胞因子水平及Thl/Th2免疫平衡指标改善均明显优于对照组，两组比较差异均有统计学意义（P＜0.05）。结论 在基础治疗上补充一定剂量的纽曼斯益生菌，可刺激患儿的肠道免疫机能，调节宿主免疫活性，增强其免疫力，减少患儿湿疹复发率，值得临床推广。

Objective To investigate the clinical efficacy and safety of probiotics in adjuvant treatment of infantile eczema. Methods One hundred cases with infantile eczema in Meishan City People's Hospital were chosen, and they were randomly divided into control (50 cases) and treatment (50 cases) groups. The patients in the control group were treated with conventional therapy. The patients in the treatment group were treated with Newmans probiotics on the basis of the control group, the children within one-year old were given half grain/d, over one-year 1－2 grains/d, between the two meals, taken by empty stomach before a meal. The efficacy of two groups was evaluated after 4 weeks. Results After the treatment, the total effective rates in the treatment group and the control group were 92.0% and 78.0%, and there were significant differences between the two groups (P<0.05). After 2- 3 months treatment, eczema recurrence rates in the treatment group were 6% and 8%, significantly lower than those in the control group 18%and 28%, and there were statistically significant (P<0.05). After 4 weeks of the treatment, the levels of cytokines and Thl/Th2 in the treatment group was significantly better improved than those in the control group. The difference between the two groups were statistically significant (P<0.05). Conclusion Newmans probiotics on the basis of basic treatment can stimulate the intestinal immune function in children and regulate the immune activity of the host, which could enhance the immunity and reduce the rate of recurrence in the children with eczema. The therapy is worth the clinical promotion.

国家自然科学基金资助项目（30901292）