目的 评价帕米膦酸二钠联合复方苦参注射液治疗恶性肿瘤骨转移所致疼痛的疗效。方法 汇总观察天津市第四中心医院肿瘤血液科自2010年10月—2013年10月恶性肿瘤骨转移病人104例，按所使用治疗方法分为治疗组和对照组，对照组单独采用注射用帕米膦酸二钠，第1天60 mg，第2天30 mg，分别加入生理盐水500 mL中缓慢静滴4 h以上，28 d为1个疗程；治疗组在对照组的基础上，第1～14天加用复方苦参注射液20 mL加入生理盐水250 mL静脉滴注。两组均治疗2个疗程。治疗结束后，比较两组患者的疼痛缓解情况、临床疗效、生活质量改善情况、血清碱性磷酸酶（ALP）水平。结果 疼痛缓解有效率治疗组为78.43%，对照组为60.38%，两组比较差异有统计学意义（P＜0.05）；生活质量改善有效率治疗组为68.63%，对照组为49.06%，两组比较差异有统计学意义（P＜0.05）；治疗后，两组ALP均明显下降，治疗组较对照组下降程度更加显著，两组差异有统计学意义（P＜0.05)。结论 在临床治疗恶性肿瘤骨转移中，帕米膦酸二钠联合复方苦参注射液可以减轻患者骨痛，改善患者生存质量，值得尽早应用。

Objective To assess the effect about pamidronate disodium combined with Compound Kushen Injection in the treatment of the pain caused by osseous metastasis of therioma. Methods Cases (104) diagnosed osseous metastasis of therioma during October 2010 to October 2013 in Tianjin 4th Central Hospital were collected and divided into treatment group and control group on the methods of treatment .The treatment group used Pamidronate Disodium for injection (first day 60 mg and second day 30 mg were added 500 mL saline respectively, kept iv drip slowly 4 h at least, one treatment course was 28 d) combined with adding 20 mL Compound Kushen Injection +500 mL saline at days 1－14 . The control group used Pamidronate Disodium for injection only. After the two courses of treatment (56 d), pain relief, clinical efficacy, quality of life, and the levels of ALP were compared between the two groups. Results The total effective rates in the treatment and the control groups were 78.43% and 60.38%, and there were the significant differences between the two groups (P<0.05). The qualities of life efficacy in the treatment and control groups were 68.63% and 49.06%, and there were significant differences between the two groups (P<0.05). ALP levels in two groups obviously decreased after the treatment, and they were dramatically reduced in the treatment group, there was a significant difference between the two groups (P<0.05). Conclusion There is a marked therapeutic effect of pamidronate disodium combined with Compound Kushen Injection in the treatment of the pain caused by osseous metastasis of therioma, which can improve the life quality of patients and should be applied as soon as possible.

天津市卫生局科基金项目（2010KZ22）