目的 建立津蓟中风Ⅰ号颗粒中梓醇和五味子醇甲的HPLC测定方法。方法 采用HPLC法分别对梓醇、五味子醇甲进行测定。梓醇的流动相为乙腈–0.1%磷酸（1∶99），体积流量为1.0 mL/min，检测波长为210 nm。五味子醇甲的流动相为甲醇–水（75∶25），体积流量为0.8 mL/min，检测波长为250 nm。结果 梓醇在4.25～68.00 μg/mL与峰面积线性关系良好，平均回收率为100.22%，RSD值为1.05%（n=9）。五味子醇甲在4.0～32.0 μg/mL与峰面积线性关系良好，平均回收率为100.49%，RSD值为1.25%（n=9）。结论 本法简便、准确性高、灵敏度高、专属性和重现性好，可作为津蓟中风Ⅰ号颗粒中梓醇和五味子醇甲的测定方法。

Objective To establish a method for the determination of schisandrin and catalpol in Jinji Zhongfeng No. 1 Granules. Methods Catalpol and schisandrin were determined by HPLC method, respectively. Catalpol was determined with acetonitrile - 0.1% phosphoric acid (1∶99) as the mobile phase, the flow rate was 1.0 mL/min, and the detection wavelength was 210 nm. Schisandrin was determined by methanol – water (75∶25) as the mobile phase, the flow rate was 0.8 mL/min, and the detection wavelength was 250 nm. Results The liner ranges of catalpol and schisandrin were 4.25 — 68.00 μg/mL (r=0.999 9), 4.00 — 32.00 μg/mL (r=0.999 9). The average recoveries were 100.22%,and 100.49%, with RSD values of 1.05%,and 1.25% (n=9), respectively. Conclusion The method is specific, accurate and reproducible, and can be used for the quality control of catalpol and schisandrin for Jinji Zhongfeng No. 1 Granules.