目的 对夏黄颗粒提取浸膏粉进行处方前粉体学和稳定性研究，为设计优良的颗粒制剂处方提供参考。方法 考察夏黄颗粒提取浸膏粉的主要粉体学参数，如堆密度、休止角、溶化性、pH值、吸湿性、临界相对湿度。以主要活性成分芦荟苷为指标，考察高温、高湿和强光照射的影响。结果 夏黄颗粒提取浸膏粉流动性较差，休止角大于45°，水溶性较好，呈弱酸性，临界相对湿度为72%；不耐高温，易吸湿，不耐光照。结论 夏黄颗粒提取浸膏粉应在密封、避光、干燥处储存。

Objective To evaluate the preformulation studies, such as micromeritic and stability studies on Xiahuang Granule extracts and to provide a reference for the design of fine particle formulation of design. Methods Powder micromeritics major parameters of Xiahuang Granule extracts, such as bulk density, angle of repose, dissolve resistance, pH value, moisture absorption, and critical relative humidity were studied. Aloin as the main active ingredient in the prescription was determined to compare the effects of high temperature, high humidity, and strong light on Xiahuang Granule extract, such as bulk density, angle of repose, dissolve resistance, pH value, moisture absorption, and critical relative humidity were studied. Results Xiahuang Granule extracts had the good water solubility with repose angle greater than 45 degrees, but poor mobility and weak acidity. The critical relative moisture of it was72%. Xiahuang Granule extracts had not been resistant to high temperature, moisture absorption, and lightfast properties. Conclusion The powder of Xiahuang Granule extracts should be stored up on sealed, dark, and dry place.

国家“十二五”科技支撑计划项目（2011BA107B01）；天津市科技计划项目（13ZCZDSY00200）