目的 观察降糖保肾宁对早期糖尿病肾病的临床疗效及早期干预的应用价值，为该病的治疗方法提供理论依据。方法 将符合纳入标准的68例受试者随机分为治疗组（34例）和对照组（34例）。两组患者均给予基础治疗，对照组口服氯沙坦钾片，50 mg/次，1次/d。治疗组口服降糖保肾宁，200 mL/次，早晚各1次。两组均治疗4周，随访6个月。治疗前后分别观察两组患者的糖化血红蛋白、空腹血糖、餐后2 h血糖、尿白蛋白排泄率、血压、血脂全项、肾功能、临床症状积分、安全性等指标的变化，判断临床疗效。随访6个月，探讨早期干预对早期糖尿病肾病的临床应用价值。结果 降糖保肾宁不仅能改善患者的症状体征，而且对患者的糖脂代谢和肾小球滤过率、肾血流、尿白蛋白水平都有很好的调节作用，与对照组比较差异有统计学意义。通过6个月的随访发现治疗组患者的病情都得到较好控制。结论 降糖保肾宁对糖尿病肾病具有较好的临床疗效，且长期疗效较好。降糖保肾宁早期干预对于早期糖尿病肾病的治疗具有临床开发价值。

Objective To observe the effect of Jiangtang Baoshenning in early diabetic nephropathy and the application value of early intervention, and to provide the theoretical foundation for the treatment in early diabetic nephropathy. Methods Patients who accorded the inclusive criteria (68 cases) were randomly divided into treatment (34 cases) and control (34 cases) groups. Two groups of patients were given the basic treatment. The patients in the control group were po administered with Losartan Potassium Tablets, 50 mg, once daily. The patients in the treatment group were po administered with Jiangtang Baoshenning, 200 mL/time, twice daily in the morning and night. Two groups were treated for 4 weeks, and followed up for 6 months. The changes of glycosylated hemoglobin, fasting blood sugar, 2 h postprandial blood glucose, urine albumin excretion rate, blood pressure, blood lipid, renal function, clinical symptoms integral, and security were observed to estimate the curative effect. The patients were followed up for 6 months to explore the clinical value of early intervention on early diabetic nephropathy. Results Jiangtang Baoshenning could not only improve the symptoms and signs of patients, but also had good adjustment function on the glucolipid metabolism, glomerular filtration rate, renal blood flow, and urine albumin levels of patients, with significant difference compared with the control group. Through 6 months of follow-up, states of illness in treatment group was better than that in the control group. Conclusion Jiangtang Baoshenning has an accurate curative effect on diabetic nephropathy, with better long-term curative effect. Early intervention of Jiangtangbaoshenning has development value for the treatment of early diabetic nephropathy.