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[摘要]
目的 分析贺州市人民医院铜绿假单胞菌的分布及耐药性变迁,为指导临床合理使用抗菌药物提供可靠依据。方法 回顾性分析2009—2013年贺州市人民医院临床各科室送检标本分离的铜绿假单胞菌,采用纸片扩散法测定抗菌药物的敏感性。结果 5年间送检标本共分离出1 544株铜绿假单胞菌,检出率为16.9%。铜绿假单胞菌的标本来源以痰液为主,占78.2%,主要来自呼吸内科、ICU、神经内科,分别占29.7%、21.2%、17.5%。药敏结果显示,铜绿假单胞菌对喹诺酮类、亚胺培南、头孢哌酮/舒巴坦耐药率相对较低,但对环丙沙星、氨苄西林、氨苄西林/舒巴坦高度耐药,且呈逐年上升趋势。结论 贺州市人民医院临床分离的铜绿假单胞菌对常用抗菌药物耐药性日益严重,因此临床上应重视监测病原菌的分布及耐药趋势,根据药敏结果合理选择抗生素,减少耐药菌株的产生。
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[Abstract]
Objective To investigate the distribution of pathogenic bacteria and drug resistance of Pseudomonas aeruginosa in People’s Hospital of Hezhou from 2009 to 2013, and to provide the certain reference for directing the clinical medication and reducing the drug resistance. Methods The distribution of P. aeruginosa isolated from various clinical specimens from 2009 to 2013 was retrospectively analyzed. The antibiotic susceptibility of bacteria was tested by disk diffusion method. Results All of 1 544 P. aeruginosa were isolated and the detection rates was 16.9% during the five years. The specimens were mainly obtained from the sputum, accounting for 78.2%. P. aeruginosa isolates were primarily from the Department of Respirtory, ICU, and Department of Neurology, accounting for 29.7%, 21.2%, and 17.5%, respetively. P. aeruginosa had the relative lower drug resistance to imipenem, cefoperazone/sulbactam, but kept higher drug resistance to ciprofloxacin, ampicillin, ampicillin/sulbactam with increasing trend year by year. Conclusion The drug resistance status of P. aeruginosa in People’s Hospital of Hezhou is more and more serious. In order to reduce the occurrence of drug resistance strains and select the antibiotics reasonably and appropriately, the attention to the distribution of pathogen and detection of drug resistance should be paid by the doctors in clinic.
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