目的 观察催产素联合间苯三酚在足月妊娠引产过程中的安全性和有效性。方法 选择单胎足月妊娠（孕周＞40周＋5 d），无阴道分娩禁忌症的待产孕妇200例，随机分为治疗组（100例）和对照组（100例），治疗组静脉滴注0.9%生理盐水500 mL＋催产素2.5 U＋间苯三酚120 mg；对照组静脉滴注0.9%生理盐水500 mL＋催产素2.5 U，两组液体滴速均从8滴/min开始调速至出现有效宫缩后维持该浓度和滴速，比较两组产妇促宫颈成熟情况（宫颈Bishop评分的变化）、引产成功率、总产程时间、产后2 h出血量及新生儿窒息情况。结果 治疗组患者的促宫颈成熟总有效率、引产成功率均明显高于对照组（P＜0.05）；治疗组总产程时间，特别是第一产程较对照组明显缩短（P＜0.05）；而产后2 h出血量和新生儿窒息情况两组比较差异无统计学意义。治疗组产妇宫颈水肿发生率明显低于对照组（P＜0.05）。结论 催产素联合间苯三酚可提高足月妊娠产妇的引产成功率，缩短总产程，但不影响母儿安全，值得临床推广应用。

Objective To observe the clinical effects and safety of oxytocin combined with phloroglucinol used for term pregnancy induction. Methods Cases (200) of single term pregnant women（gestational weeks≥40 weeks + 5 d）without any taboo of vaginal delivery were randomly divided into the treatment (100 cases) and control (100 cases) groups. The patients in the treatment group were iv administered with physiological saline 500 mL+oxytocin 2.5 U+phloroglucinol 120 mg, while the patients in the control group were iv administered with physiological saline 500 mL+oxytocin 2.5 U. The liquid drip speed of both groups began from 8 drops/min until appearance of effective contractions, maintained the speed and concentration. The cervical maturity (the change of Bishop scoring) before and after treatment, the success rate of induction, the time of birth process, and the amount of bleeding in 2 h postpartum and incidence of neonatal asphyxia were compared between the two groups. Results The effective rate of prompt cervical maturity and success rate of induction in the treatment group were obviously higher than those in the control group (P < 0.05). The time of labor especially the time of first stage of labor in the treatment group was obviously shorter than those in the control group (P < 0.05). There was no difference in the amount of bleeding in 2 h postpartum and the incidence of neonatal asphyxia between the two groups. Conclusion Oxytocin combined with phloroglucinol could improve the success rate of term pregnancy induction and shorten the total birth process time. It is safety for mother and child, which is worthy of clinical application.