目的 考察球磨粉碎技术对刺五加中有效成分提取的影响。方法 采用超声、冷浸法处理，以紫丁香苷、刺五加苷E、异嗪皮啶质量分数为指标，采用高效液相色谱法比较了不同处理时间的刺五加球磨粉、粗粉、中粉和细粉。结果 随着粉碎粒度的变细，刺五加中有效成分提取率明显提高，球磨粉–超声＞球磨粉–冷浸＞细粉–超声＞中粉–超声＞粗粉超声＞中粉–冷浸＞细粉–冷浸＞粗粉–冷浸。其中球磨粉超声60 min与常规粉碎的粗粉、中粉及细粉超声60 min对比，紫丁香苷提高11.05%～56.56%、刺五加苷E提高26.04%～114.74%、异嗪皮啶提高24.10%～84.64%。结论 球磨粉碎技术能够有效地提高刺五加中有效成分的提取率和提取速率，缩短样品前处理时间，值得推广应用。

Objective To study the effect of ball pulverizing technology on extraction of the effective constituents in Acanthopanacis Senticosi Radix et Caulis. Methods Ultrasonic and cold leaching extract methods were used by using syringoside, eleutheroside E, and isofraxidin contents as indexes, and the ball pulverizing powder, coarse powder, middle powder, and fine powder treated in different times were compared by HPLC method. Results As the particle size was becoming finer, the leaching of the effective component in Acanthopanacis Senticosi Radix et Caulis was increased remarkably, namely ball pulverizing – ultrasonic > ball pulverizing-cold leaching > fine powder – ultrasonic > powder – ultrasonic > coarse powder – ultrasonic > powder-cold leaching > fine powder–cold leaching > coarse powder-cold leaching. Among them syringin increased 11.05% — 56.56%, eleutheroside E 26.04% — 114.74%, and isofraxidin 24.10% – 84.64%. Conclusion Ball pulverizing technology could effectively promote the extraction of the effective constituents in Acanthopanacis Senticosi Radix et Caulis, shorten the sample preparation time, which could be worthy of popularization and application.