目的 考察制备的芒果苷脂质体的理化性质和经皮渗透性能。方法 采用薄膜分散法制备芒果苷脂质体，超速离心法测定包封率，并对粒径、电位进行表征；以大鼠皮肤为渗透屏障，采用Franz扩散池比较芒果苷脂质体和水溶液的体外经皮累积渗透量。结果 芒果苷脂质体的粒径为（97.7±1.2）nm、电位为（?10.7±0.2）mV，包封率为44.1%。芒果苷脂质体组与水溶液组24 h累积渗透量分别为（171.9±13.43）、（102.5±3.97）μg/cm2。结论 脂质体给药系统可有效促进芒果苷的经皮渗透，为芒果苷经皮给药新制剂的研究提供了参考。

Objective To investigate the physicochemical property and percutaneous permeability of mangiferin liposomes. Methods Film dispersion method was used to prepare mangiferin liposomes and entrapment efficiency was determined by ultracentrifugation. Particle size and Zeta potential were characterized. Using rat skin as a permeability barrier, accumulation of percutaneous penetration in vitro between mangiferin liposomes and aqueous was compared in Franz diffusion cell. Results The particle size, Zeta potential, and encapsulation efficiency of mangiferin liposomes were (97.7 ± 1.2) nm, (?10.7 ± 0.2) mV, and 44.1%, respectively. The cumulative permeation amount of mangiferin liposome and aqueous was (171.9 ± 13.43) and (102.5 ± 3.97) μg/cm2. Conclusion Liposome delivery system could effectively promote the percutaneous penetration of mangiferin, and provide the experimental reference for new mangiferin transdermal preparations study.