目的 观察替硝唑片联合盐酸米诺环素软膏辅助根管治疗牙周–牙髓联合病变的临床疗效。方法 选取常州市口腔医院2009年3月—2013年3月收治的牙周–牙髓联合病变患者100例，将其随机分为治疗组（50例）和对照组（50例），治疗组患者采用盐酸米诺环素软膏根管疗法，术后口服替硝唑片，0.5 g/次，1次/d，连服3 d；对照组患者采用常规根管治疗，同时口服替硝唑片，用法用量同治疗组。所有患者治疗后1周复查探诊深度（PD）、探诊出血（BOP），并观察治疗后1个月的临床疗效和不良反应。结果 两组患者治疗1周后复查PD、BOP情况较治疗前均有明显改善，差异均有统计学意义（P＜0.05）。治疗后，治疗组PD、BOP情况优于对照组，组间比较差异有统计学意义（P＜0.05）。治疗后1个月，对照组患者有效率为66%，治疗组为92%，治疗组有效率明显高于对照组，差异有统计学意义（P＜0.05）。结论 替硝唑片联合盐酸米诺环素软膏辅助根管治疗牙周–牙髓联合病变，可以有效提高患者的治疗有效率，且不良反应没有增加，值得临床应用。

Objective To observe the efficacy of Tinidazole Tablets combined with Minocycline Hydrochloride Ointment (TT-MHO) auxiliary root canal therapy in treatment of periodontal-endodontic lesions. Methods The patients (100 cases) diagnosed with periodontal-endodontic lesions in Changzhou Stomatological Hospital from March 2009 to March 2013 were randomly divided into treatment (50 cases) and control (50 cases) groups. The patients in the treatment group were administered with root canal therapy by MHO, and were po administered with TT for 3 d, 0.5 g/time, once daily. The patients in the control group were treated by conventional root canal therapy, and po administered with TT, and the usage and dosage were the same as the treatment group. The probing depth (PD) and bleeding on probing (BOP) were reviewed 1 week after treatment. The clinical efficacy and adverse reactions were observed one month after treatment. Results The situation of PD and BOP were obviously improved in both groups (P < 0.05) one week after treatment. PD and BOP in the treatment group were better than those in the control group with significant difference (P < 0.05). The efficiency for the patients in both groups was 92% and 66% with significant difference (P < 0.05) one month after treatment. Conclusion TT-MHO auxiliary root canal therapy in treatment of periodontal-endodontic lesions could improve the efficiency effectively, and the adverse reactions do not increase, which could be used in clinic .