目的 将蒙花苷制备成固体分散体，提高其体外溶出度。方法 分别以不同辅料为载体，采用溶剂法、熔融法或溶剂–熔融法制备蒙花苷固体分散体，以蒙花苷的体外溶出度为指标，考察蒙花苷固体分散体的最佳处方和制备工艺。并采用差示热分析法和X射线粉末衍射法对蒙花苷固体分散体物相进行表征。结果 蒙花苷与聚乙二醇6000质量比为1∶9，采用熔融法制备的固体分散体的体外溶出最好。结论 以聚乙二醇6000为载体制备的蒙花苷固体分散体可以显著提高蒙花苷的体外溶出度，且以过饱和的固态溶液或无定型状态均匀分布在载体中。

Objective To prepare linarin solid dispersion and improve the dissolution rate of linarin in vitro. Methods The solid dispersion of linarin was prepared by the solvent, melted, and solvent-melted methods with different excipients as carriers, respectively. To study the best prescription and preparation process, the dissolution characteristics of the solid dispersion in vitro were measured by HPLC, and properties of solid dispersion were studied by DSC and X-ray. Results The in vitro dissolution of linarin solid dispersion prepared by the melted method was the best with linarin-poly ethylene glycol (PEG) 6000 (1∶9). Conclusion The in vitro dissolution of linarin is significantly increased by linarin solid dispersion prepared by melted method with PEG 6000 as the carrier. Linarin is completely dispersed in carriers with supersaturated solid solution or amorphous state.