目的 研究乳香中醋酸乙酯部位的化学成分。方法 采用正反相硅胶柱色谱和重结晶等技术对其醋酸乙酯部位中的化学成分进行分离和纯化，并根据波谱数据鉴定化合物的结构。结果 分离得到9个化合物，分别鉴定为3α-乙酰氧基-甘遂-7,24-二烯-21-酸（1）、3α-乙酰氧基-羊毛甾-8,24-二烯-21-酸（2）、3-羰基-甘遂-8,24-二烯- 21-酸（3）、3β-羟基-羊毛甾-8,24-二烯-21-酸（4）、3-乙酰基-11-羰基-β-乳香酸（5）、3-乙酰基-α-乳香酸（6）、3-乙酰基-β-乳香酸（7）、incencole oxide acetate（8）、棕榈酸（9）。结论 化合物1是首次从天然资源中分离得到，化合物9为首次从乳香中分离得到。

Objective To study the chemical constituents in the ethyl acetate fraction from Olibanum. Methods The chemical constituents in the ethyl acetate fraction from Olibanum were isolated and purified by methods of column chromatography (silica gel, including reversed phase) and recrystallization, and their structures were identified on the basis of spectroscopic data. Results Nine compounds were separated and identified as 3α-acetoxy-tirucall-7,24-dien-21-oic acid (1), 3α-acetoxylanosta-8,24-dien-21-oic acid (2), 3-keto-tirucall-8,24-dien-21-oic acid (3), 3β-hydroxylanosta-8,24-dien-21-oic acid (4), 3-acetyl-11-keto-β-boswellic acid (5), 3-acetyl-α-boswellic acid (6), 3-acetyl-β-boswellic acid (7), incencole oxide acetate (8), and palmitic acid (9). Conclusion Compound 1 is isolated from natural source for the first time and compound 9 is found from Olibanum for the first time.

国家重大新药创制专项（2011ZX09401-009）