目的 对咪达那新的合成工艺进行研究。方法 以二苯乙腈为起始原料，与1,2-二溴乙烷经相转移反应生成4-溴-2,2-二苯基丁腈（1），化合物1在三乙胺存在下，于N,N-二甲基甲酰胺–二甲基亚砜中与2-甲基咪唑反应，生成4-(2-甲基-1H-咪唑-1-基)-2,2-二苯基丁腈（2），化合物2在70%硫酸溶液中，经水解、精制得咪达那新。结果 该合成工艺总收率为40.2%，终产物质量分数为99.9%。结论 工艺改进后，简化了操作过程，提高了咪达那新的收率。

Objective To study the synthetic technology of imidafenacin. Methods Using 1,2-dibromomethane as the starting material, 4-bromo-2,2-diphenylbutyronitrile (1) was obtained after the phase transfer reaction with diphenylacetonitrile; compound 1 was then condensed with 2-methylimidazole in the presence of triethylamine in hot DMF-DMSO to obtain 4-(2-methyl-1-imidazolyl)- 2,2-diphenylbutyronitrile (2). Imidafenacin was obtained according to the hydrolysis of compound 2 in the presence of 70% sulfuric acid. Results The total yield by the synthetic process was 40.2%, and the purity of imidafenacin was 99.9%. Conclusion After the improvement of the process, the operating process is simplified and the yield of imidafenacin is improved.