目的 观察六味地黄丸对早期糖尿病肾病患者的临床疗效及其安全性。方法 选择天津市滨海新区大港港西街社区卫生服务中心2010年4月—2013年4月收治的早期糖尿病肾病患者72例，随机分为治疗组（36例）和对照组（36例），对照组给予饮食及运动疗法，同时用阿卡波糖治疗，餐前服用，100 mg/次，3 次/d；治疗组在对照组治疗的基础上加用六味地黄丸治疗，6 g/次，2 次/d。治疗两个月后，比较两组患者24 h尿蛋白、血糖、血脂及尿微量白蛋白的变化，同时观察两组不良反应的发生情况。结果 两组患者治疗前后24 h尿蛋白、血糖、血脂及尿微量白蛋白自身对照有明显差异（P＜0.05）；治疗组患者各项指标改善明显优于对照组（P＜0.05），两组患者不良反应发生情况比较差异没有统计学意义。结论 阿卡波糖联合六味地黄丸治疗对于早期糖尿病肾病患者有较好的临床疗效，值得临床应用。

Objective To observe the clinical efficacy and safety of the early diabetes nephropathy patients with Liuwei Dihuang Pill (LDP) treatment. Methods Patients (72 cases) with early diabetic nephropathy from April 2010 to April 2013 in Tianjin Binhai New Area of Dagang Port West Street Community Health Service Center were randomly divided into treatment group (36 cases) and control group (36 cases). Each group was given a diet and exercise therapy, while the control group with acarbose treatment (before meals, each 100 mg, 3 times a day) and the treatment group with LDP treatment (6 g/time, twice a day). After the treatment for two months, the patients in two groups were compared within 24 h urine protein, blood sugar, blood fat, and urine trace albumin quantitative differences, adverse drug reactions and other changes. Results The patients of pre- and post-treatment self-reflection in the two groups had significant differences (P < 0.05); the improvement of each index of patients in the treatment group was superior to those in the control group (P < 0.05). The patients with adverse reaction conditions in the two groups had no statically significant differences (P > 0.05). Conclusion Acarbose combined with LDP has an accurate curative effect on early diabetic nephropathy, which is worthy of clinical promotion and application.