目的 观察左布比卡因颈椎旁神经阻滞联合臭氧治疗青少年颈源性头痛的临床疗效。方法 将患有颈源性头痛的青少年患者168例随机分为对照组（84例）和治疗组（84例）。对照组应用左布比卡因行颈椎旁神经阻滞，治疗组在对照组基础上加用臭氧进行治疗，2～3次为1个疗程，两组各治疗1个疗程。两组患者治疗前及治疗结束后7 d、1个月和3个月进行评价临床疗效和不良反应。结果 与治疗前相比，两组患者治疗后7 d、1个月、3个月的VAS评分均有明显降低，其差异具有统计学意义（P＜0.05）。在治疗后7 d治疗组的疼痛评分、头痛发作次数及每次发作时间与对照组相比均明显降低，差异均具有统计学意义（P＜0.05）；治疗组在治疗后7 d，治愈32例，明显好转39例，显效率为84.5%，同期，对照组治愈21例，明显好转31例，显效率为61.9%，对照组显效率明显低于治疗组，差异有统计学意义（P＜0.05），且无不良反应发生。结论 左布比卡因颈椎旁神经阻滞疗法联合臭氧治疗青少年颈源性头痛的临床疗效优于单纯颈椎旁神经阻滞，值得临床应用。

Objective To explore the clinical efficacy of paravertebral neural blockade by levobupivacaine combined with ozone for cervicogenic headache among the adolescent patients. Methods A total of 168 cases with cervicogenic headache were randomly divided into control (84 cases) and treatment (84 cases) groups. The patients in the control group were treated with the method of pure paravertebral neural blockade and the patients in the treatment group were treated with paravertebral neural blockade combined with ozone. Each case had a course of 2—3 times’ treatment. The clinical efficacy and adverse effect were compared at the time of before the treatment and 7 d, 1 month, and 3 months after the treatment. Results Compared with the situation before the treatment, receiving the treatment 7 d, 1 month, and 3 months later, VAS scores in both groups were significantly lower than before and had the statistically significant difference (P<0.05). Pain scores, the number of headache attacks and the duration in the test group were significantly lower than those in the control group 7 d after the treatment. In the treatment group, 32 cases were cured and 39 cases were significantly improved with the efficacy rate of 84.5% 7 d after the treatment. At the same time, in the control group, 21 cases were cured and 31 cases were significantly improved with the efficacy rate of 61.9%, which was significantly lower than those in the treatment group and had the statistically significant difference (P<0.05). No adverse effect was observed in the test group. Conclusion The clinical efficacy of paravertebral neural blockade by levobupivacaine combined with ozone for cervicogenic headache among the adolescent patients is better than the method of paravertebral neural blockade only, which is worthy of clinical application.