目的 观察甲基强的松龙联合环磷酰胺治疗Churg-Strauss综合征（CSS）的临床疗效及安全性。方法 回顾性分析2004年1月至2012年5月4例伴有肾损害的CSS病例应用甲基强的松龙联合环磷酰胺治疗的疗效及安全性。结果 CSS伴肾脏受累者应用甲基强的松龙联合环磷酰胺治疗后，均获得临床缓解，且肾功能恢复良好，同时未见明显不良反应。结论 甲基强的松龙联合环磷酰胺治疗合并肾脏损害的CSS治疗有效，且不良反应小。

Objective To observe the efficacy and safety of methyl prednisolone combined with cyclophosphamide in treatment of Churg-Strauss syndrome (CSS). Methods The efficacy and safety of methyl prednisolone combined with cyclophosphamide in four patients diagnosed as CSS with kidney injury during January 2004 and November 2012 were retrospectively analysed. Results All the patients achieved the total clinical remission and recovery of renal function after treated with methyl prednisolone and cyclophosphamide without obvious side effects. Conclusion Methyl prednisolone combined with cyclophosphamide is effective to CSS with kidney injury without obvious side effects.