目的 研究胃散对胃溃疡大鼠胃黏膜的保护作用。方法 采用乙酸烧灼型胃溃疡模型、幽门结扎型胃溃疡模型、乙醇损伤型胃溃疡模型，检测溃疡指数、胃酸总酸度、胃酸分泌速度和胃蛋白酶活性，综合考察胃散对胃溃疡模型大鼠胃黏膜的保护作用。结果 胃散在1、0.5、0.25 g/kg剂量下，对乙酸烧灼型胃溃疡有非常显著的促愈合作用；对幽门结扎型胃溃疡的形成有显著的抑制作用；对乙醇损伤的胃黏膜也有显著的保护作用；对胃液总酸度、胃酸分泌速度和胃蛋白酶活性有明显抑制作用，显著增加胃液分泌量。结论 胃散具有增加胃液分泌、抑制胃酸分泌、抑制胃蛋白酶活性、保护胃黏膜和防止胃溃疡的作用。

Objective To study the gastric mucosa protection activity of Wei San on rats with gastric ulcer. Methods The gastric mucosa protection effect of Wei San was evaluated by detecting the ulcer index (UI), total acidity of gastric juice, the secretion speed of gastric acid and pepsin activity on rats with gastric ulcer induced by acetic acid, pylorus ligation and alcohol. Results Wei San showed a significant healing promoting effect in acetic acid-induced gastric ulcer model, showed a depressant effect on the formation of gastric ulcer in pylorus ligation model, and displayed a marked protection effect on gastric mucosa in alcohol-induced gastric ulcer model by ig administered with the dosages of 1, 0.5, and 0.25 g/kg. Meanwhile, Wei San had a marked depressant effect on the total acidity of gastric juice, the secretion speed of gastric acid and the pepsin activity, also increased the gastric juice secretory volume. Conclusion Wei San has the potential efficacy on gastric ulcers by increasing gastric juice secretion and inhibiting gastric acid secretion and pepsin activity.