目的 探讨万古霉素致不良反应的特点及相关因素，为临床合理用药提供参考。方法 检索2001—2013年国内医药期刊报道的40例万古霉素致不良反应案例，并进行统计、分析。结果 万古霉素所致不良反应主要表现为药热、肾衰竭、过敏反应等。结论 临床应加强万古霉素的合理使用，尽量避免或减少其所致不良反应的发生。

Objective To study the characteristics and related factors of the adverse drug reaction (ADR) induced by vancomycin, so as to provide the references for the rational use of drugs in clinic. Methods Forty cases of ADR induced by vancomycin, which were reported in domestic medical academic journals from 2001 to 2012, were statistically analyzed. Results The ADR induced by vancomycin is mainly radiation, kidney failure, allergic reaction, and so on. Conclusion The rational use of vancomycin should be emphasized to avoid or reduce the incidence of ADR.