目的 分析天津市第三中心医院开展抗菌药物临床应用专项管理前后各科室的抗菌药物管理指标，为抗菌药物合理应用提供依据。方法 根据天津市第三中心医院信息系统（HIS）数据，回顾性收集管理前后2011年1～7月份与2012年1～7月份的抗菌药物相关数据，根据世界卫生组织定义的限定日剂量（defined daily dose，DDD），计算抗菌药物使用强度（antibacterial use density，AUD）。将相关数据运用Excel 2003软件电子表格进行分类、汇总及筛选，评价相关指标对AUD的影响，分析降低AUD的措施是否有效。结果 管理后天津市第三中心医院抗菌药物使用率及AUD、Ⅰ类切口手术预防用抗菌药物使用率均明显下降，病原学送检率明显升高，2012年所有指标均达到卫生部抗菌药物应用指标要求。结论 天津市第三中心医院抗菌药物专项管理措施很有成效。

Objective To provide the evidence for the rational use of antibacterials in clinic through analysis on the controlling indicators of all divisions before and after special clinical antibacterial managements in Tianjin Third Center Hospital. Methods According to Tianjin Third Center Hospital information system (HIS), the data of antibacterials used from January to August in 2011 and 2012 before and after management were collected and analyzed by Excel 2003 with retrospective study. According to World Health Organization defined daily dose (DDD), we calculated the antibacterial use density (AUD). We evaluated the impact of relevant indicators for AUD, and analyzed the effectiveness of measures to reduce AUD. Results The antibacterial usage, AUD, and the preventive use of antibiotics of type I incision in Tianjin Third Center Hospital after management have decreased. The rate of pathogenic detection had significantly increased. All indicators in 2012 had reached the grade of Ministry of Health in our country. Conclusion The special managements in Tianjin Third Center Hospital are efficacy.