目的 研究利克飞龙的抗炎作用。方法 通过ig给药，观察利克飞龙对大小鼠的抗炎活性以及炎性因子水平。结果 ig利克飞龙（60 mg/kg）对小鼠耳肿胀及角叉菜胶引起大鼠足趾肿胀抑制作用与甲泼尼龙（60 mg/kg）相当，利克飞龙给药一周对小鼠体质量正常生长没有影响，利克飞龙对炎性因子前列腺素E2（PGE2）含量降低作用与塞来昔布相当。结论 利克飞龙具有高效的抗炎作用，其抗炎作用与甲泼尼龙相当，其降低PGE2作用与塞来昔布相当，且利克飞龙为COX/5-LOX双靶标抑制剂，理论上安全性更高，患者可长期服用，有望成为临床上非甾体抗炎药中的首选药物之一。

Objective To study the anti-inflammatory effect of licofelone. Methods By ig administration, anti-inflammatory activity and inflammatory factor levels of licofelone were observed. Results The inhibition of licofelone (60 mg/kg) on ear swelling of mice and carrageenan-induced paw edema of rats were similar to those of methylprednisolone (60 mg/kg). Licofelone treatment for one week did not affect the normal growth of the body weight of mice. The decreasing of inflammatory factor PGE2 by licofelone was similar to that of celecoxib. Conclusion Licofelone has high anti-inflammatory effect, which is equivalent to that of methylprednisolone, and its anti-PGE2 effect is equivalent to that of celecoxib. Licofelone is an inhibitor for COX/5-LOX dual target, theoretically more secure, and could be long-term used in patients. It is expected to become one of the preferred drugs of non-steroidal anti-inflammatory drugs in clinic.