目的 比较亮丙瑞林和曲普瑞林治疗子宫内膜异位症（EMs）的近期不良反应与激素水平的下降情况。方法 将80例卵巢子宫内膜异位囊肿剥除术后的患者随机分成2组，进行前瞻性临床观察。术后亮丙瑞林组注射亮丙瑞林3.75 mg，曲普瑞林组注射曲普瑞林3.75 mg，两组均治疗3～6个月，每28～30 天 1次。观察2组的近期不良反应，同时测定用药第0、7、21 天血清卵泡刺激素（FSH）、促黄体激素（LH）和雌二醇（E2）水平。结果 亮丙瑞林组27例与曲普瑞林组33例全程完成了治疗。两组患者均可发生潮热、盗汗，痤疮，肌肉、关节痛，头痛，异常阴道出血等不良反应，痤疮、头痛的发生率两组有显著性差异（P＜0.01，0.05）。两组患者用药前基础性激素水平差异无统计学意义；用药治疗7 d后血清FSH、LH、E2水平差异均有统计学意义（P＜0.05，0.01）；用药治疗21 d后血清FSH、E2水平差异均有统计学意义（P＜0.01）。结论 亮丙瑞林与曲普瑞林治疗子宫内膜异位症后其激素水平变化和近期不良反应均不同。亮丙瑞林治疗后激素水平下降缓和，不良反应发生率低。临床上应该根据不同剂型的特点，实施个体化治疗。

Objective To compare the side effects and decrease of hormone level in the treatment of endometriosis (EMs) using Triptorelin and Leuprorelin. Methods Ovarian endometriosis patients (80 cases) after cystectomy were randomly divided into two groups to do prospective clinical observation. Patients in groups Leuprorelin and Tritorelin were iv injected with Leuprorelin 3.75 mg and Tritorelin 3.75 mg, respectively for 3—6 months and 28—30 d once. The side effects in the two groups were observed, and the follicle-stimulating hormone (FSH), luteotropic hormone (LH), and estradiol (E2) levels on days 0, 7, and 21 were determined. Results Patients in Triptorelin (33 cases) and Leuprorelin (27 cases) completed the therapy. Side effects such as hot flashes, night sweats, acne, muscle pain, joint pain, headache, abnormal vaginal bleeding happened in patients in the treatment groups. Acne, headache incidence showed the significant difference between the two groups (P＜0.01, P＜0.05). Sex hormone levels in patients of the two groups showed no significant difference (P＞0.05); FSH, LH, and E2 levels on the day 7 after administration all had the significance (P＜0.01, P＜0.05). FSH and E2 levels in the two treatment groups both had the significance (P＜0.01). Conclusion The side effects and hormone level in Triptorelin and Leuprorelin are different in the treatment of EMs. Leuprorelin treatment could slowly decrease the hormone level and the side effect is low. Individualized treatment should be carried out according to the characteristics of the different preparations in clinic.