目的 考察以乳糖、甘露醇为辅料对骨疏灵颗粒吸湿性和成型性的影响。方法 考察单一辅料和混合辅料对骨疏灵颗粒的成型性、吸湿性的影响，采用单因素试验优选浸膏与辅料的配比。结果 综合吸湿性、成型性和制粒难易程度，以浸膏与混合辅料（乳糖、甘露醇比例为4∶1）1∶2的比例防潮效果最好。结论 乳糖和甘露醇通过适当配比能明显降低骨疏灵颗粒的吸湿性，提高成型性。

Objective To study the influence of lactose and mannitol as excipients on formability and hygroscopicity of Gushuling Granule. Methods Effects of single and mixed excipients on formability and hygroscopicity of Gushuling Granule were studied and single factor test was carried out to optimize the ratio of extraction and excipients. Results The best damp-proofing excipients integrated with formability, hygroscopicity, and granulation difficulty degree were extraction-excipient (lactose-mannitol by 4:1 ratio) at 1:2 ratio. Conclusion Appropriate ratio of lactose-mannitol could reduce the hygroscopicity and improve the formability of Gushuling Granule.