固相萃取技术是一种在20世纪70年代初发展起来的样品预处理分离富集技术，具有操作简单、省时，易实现自动化等优点，广泛应用在制药、食品、环境、商检、化工等领域。固相萃取技术与高效液相色谱（HPLC）或液相色谱（LC）、质谱（MS）法等分离检测手段联用，从而实现样品在线预处理，使其在组合化学、高通量筛选等药学领域的应用日益增多。简要介绍了固相萃取技术在化学药、中药及天然药物、生物药中的应用。

Solid phase extraction technology is a sample pretreatment and enrichment technology, developed in the early 1970s, with the advantages of simple procedure, short time, and easy automation, etc. It is widely used in the fields of pharmacy, food, environment, commercial inspection, chemical industry, and so on. Solid phase extraction technology, combined with the separation detection methods of high performance liquid chromatography (HPLC), liquid chromatography (LC), or mass spectrometry (MS), could accomplish the online sample pretreatment and increase its application in combinatorial chemistry and high flux screening of pharmacy. This review briefly introduces the application of solid phase extraction technology in pharmaceutical chemicals, traditional Chinese medicine, natural medicine, and biological medicine.