目的 建立帕拉米韦三水合物原料药中帕拉米韦的测定方法。方法 以0.1 mol/L高氯酸溶液为滴定液，以冰醋酸为溶剂，采用非水滴定法进行测定。结果 帕拉米韦样品溶液6 h内稳定；重复性测定结果表明RSD值为0.07%（n=6）。结论 该方法简单、准确，具有良好的重复性和稳定性，可作为帕拉米韦原料药的测定方法，为帕拉米韦的质量控制提供科学依据。

Objective To establish a method for the determination of peramivir in peramivir bulk drug . Methods The contents were performed by nonaqueous titration method with 0.1 mol/L perchloric acid solution as titrant and with glacial acetic acid as solvent. Results Peramivir sample solution was stable within 6 h. Relative standard deviation (RSD) of repeatability was 0.07% (n=6). Conclusion The established method is simple and accurate with good repeatability, which could be applied for the determination of peramivir bulk drug and provide the scientific evidence for the quality control of peramivir bulk drug.