目的 研究生脉散超微粉的显微特征和溶出度差异，为生脉超微粉应用提供实验依据。方法 采用光学显微镜观察颗粒显微结构；电镜扫描观察微观形貌；以五味子甲素和五味子乙素为指标，采用HPLC法测定生脉散细粉和超微粉在不同时间溶出的量，计算累积溶出度。结果 生脉散经超微粉碎后，基本无完整细胞存在，粒度均匀；生脉散超微粉中五味子甲素和五味子乙素溶出速率高于细粉，但是180 min后累积溶出量没有明显差异。结论 超微粉碎可使生脉散显微特征变化明显，化学成分五味子甲素和五味子乙素溶出速率加快。

Objective To study the micro-characteristic and dissolution of ultra-micro powder in Shengmai Powder, and to provide experimental foundation for the application of ultra-micro powder in Shengmai Powder. Methods The microstructure was observed by light microscope and the micro shape was observed by .electron microscope scanning. The dissolutions of Shengmai Powder and ultra-micro powder in Shengmai Powder at different time were determined by HPLC using schizandrins A and B as indexes. Results Compared with the common powder, the cellules of ultra-micro powder were pulverized, and the particles were tiny without intact cells and uniform. The cumulative dissolution rates of schizandrins A and B in ultra-micro powder were higher than those in the traditional common powder, but there was no significant difference after 180 min. Conclusion The micro-characteristic of ultra-micro powder in Shengmai Powder is obviously changed after ultrafine grinding, and the dissolution velocity of schizandrins A and B increases.

国家重点基础研究发展计划（973计划）项目（2010CB735604）