2型糖尿病是一种慢性代谢障碍性疾病，呈进行性发展，很难治愈，占糖尿病的90%以上。目前治疗该病的药物有很多，包括传统药物如磺脲类、格列奈类、噻唑烷二酮类、双胍类和α-葡萄糖苷酶抑制剂，以及近些年出现的新作用机制药物如GLP-1受体激动剂、DDP-IV抑制剂和SGLT2抑制剂。对上述各类药物的研究情况进行综述。

Type 2 diabetes is a kind of chronic metabolic disorders and progressive diseases difficult to cure, which is accounting for more than 90% of the diabetes. Currently, there are a lot of drugs for the treatment of type 2 diabetes, including the traditional drugs such as sulfonylureas, glinides, thiazolidinediones, biguanides, and α-glucosidase inhibitor, and drugs with new mechanism developed in recent years, such as GLP-1 receptor agonist, DDP-IV inhibitor, and SGLT2 inhibitors. This article reviewed the research and development of the above types of drugs.