[关键词]
[摘要]
近些年来,二肽基肽酶Ⅳ(dipeptidyl peptidase IV,DPP-IV)抑制剂在治疗2型糖尿病的药物中异军突起,DPP-IV是一种2型多功能跨膜细胞表面糖基化蛋白,在临床治疗和临床试验中,发现了很多DPP-IV抑制剂潜在的药理作用。通过对国内外相关文献的检索,对DPP-IV抑制剂包括降糖、保护心脏、抗炎等药理作用进行了综述。
[Key word]
[Abstract]
In recent years, the dipeptidyl peptidase IV (DPP-IV) inhibitors have been used for the treatment of type 2 diabetes. DPP-IV inhibitor is a kind of type 2 multifunctional transmembrane cell surface glycosylation protein, and lots of the potential pharmacological effects of DPP-IV inhibitors have been reported in the clinical treatment and trials. In this paper, the major pharmacological effects of DPP-IV inhibitors including hypoglycemic, cardiovascular system preservation, anti-inflammatory actions, etc. have been summarized through searching the related references at home and abroad.
[中图分类号]
[基金项目]
辽宁省重点大学科学研究项目(L2010433)