目的 研究四君补铁生血颗粒治疗脾气虚型缺铁性贫血的临床疗效。方法 将60例脾气虚型缺铁性贫血患者随机分为两组，治疗组30例，对照组30例。治疗组饭后口服四君补铁生血颗粒1包/次，3次/d，对照组饭后口服枸橼酸铁片2片/次，3次/d，两组疗程均为3个月，随访3个月。观察治疗前后血红蛋白量、红细胞数、血清铁蛋白、中医症状评分变化，同时观察不良反应的情况。结果 治疗后两组血红蛋白、红细胞均明显高于治疗前，中医征候评分明显降低；临床症状改善，血红蛋白量、红细胞数、血清铁蛋白升高，治疗组明显优于对照组；治疗组的不良反应明显低于对照组。结论 四君补铁生血颗粒治疗脾气虚型缺铁性贫血在改善临床症状、促进铁吸收、升高血红蛋白和红细胞方面优于枸橼酸铁片，且不良反应明显少于枸橼酸铁片，值得临床进一步研究。

Objective To study the clinical efficacy of Sijun Butie Shengxue Granules (SBSG，used for supplement of iorn) on the treatment of iron deficiency anemia (IDA) induced by spleen-Qi deficiency (SQD). Methods A total of 60 patients with IDA induced by SQD were randomly divided into treatment (30) and control (30) groups. The patients in the treatment group were po administered with SBSG, a packet once after a meal, three times daily; The patients in the control group were po administered with ferric citrate tablets, two tablets once after a meal, three times daily; Both of the two groups were consecutively adminstered for three months; And the patients were followed up for three months. The amount of hemoglobin, red blood cell count, serum ferritin, and the symptom score change of traditional Chinese medicines (TCM) were observed before and after the treatments and the adverse reactions of SBSG were observed as well. Results After the treatment, the amount of hemoglobin and red blood cell acount were significantly increased, and the symptom score change of TCM was significantly decreased. The clinical symptoms were improved, the amount of hemoglobin, red blood cell count, and serum ferritin in the treatment group were significantly increased, and the adverse reactions in the treatment group were significantly lessened compared with the control group. Conclusion SBSG could significantly improve the clinical symptoms of patients with IDA induced by SQD, help iron absorption, and increase hemoglobin and red blood cells in the treatment group better than ferric citrate tablets, which is worthy of further study in clinic.

陕西省中医管理局科研招标课题（1c19）